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Srjdan Prodanovich, MD; Robert S. Kirsner, MD, PhD; Jeffrey D. Kravetz, MD; Fangchao Ma, MD, PhD; Lisa Martinez, MD; Daniel G. Federman, MD

Arch Dermatol. 2009;145(6):700-703.

Objective  To examine the cardiovascular risk factors in patients with psoriasis and the association between psoriasis and coronary artery, cerebrovascular, and peripheral vascular diseases.

Design  Observational study.

Setting  Large Department of Veterans Affairs hospital.

Patients  The study included 3236 patients with psoriasis and 2500 patients without psoriasis (controls).

Main Outcome Measures  Using International Classification of Diseases, Ninth Revision, Clinical Modification, codes, we compared the prevalence of traditional cardiovascular risk factors and other vascular diseases as well as mortality between patients with psoriasis and controls.

Results  Similar to previous studies, we found a higher prevalence of diabetes mellitus, hypertension, dyslipidemia, and smoking in patients with psoriasis. After controlling for these variables, we found a higher prevalence not only of ischemic heart disease (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.51-2.11) but also of cerebrovascular (OR, 1.70; 95% CI, 1.33-2.17) and peripheral vascular (OR, 1.98; 95% CI, 1.32-2.82) diseases in patients with psoriasis compared with controls. Psoriasis was also found to be an independent risk factor for mortality (OR, 1.86; 95% CI, 1.56-2.21).

Conclusions  Psoriasis is associated with atherosclerosis. This association applies to coronary artery, cerebrovascular, and peripheral vascular diseases and results in increased mortality.

Author Affiliations: Departments of Dermatology and Cutaneous Surgery (Drs Prodanovich, Kirsner, and Martinez) and Epidemiology and Public Health (Dr Kirsner), University of Miami Miller School of Medicine, and Department of Dermatology, Miami Veterans Affairs Medical Center (Dr Kirsner), Miami, Florida; Departments of Medicine, Veterans Affairs Connecticut Health Care, West Haven (Drs Kravetz and Federman), and Yale University School of Medicine, New Haven (Drs Kravetz and Federman), Connecticut; and Epidemiologic Studies, Illinois Department of Public Health, Springfield, Illinois (Dr Ma).

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