Diagnosis: Generalized eruptive histiocytoma (GEH).
MICROSCOPIC FINDINGS AND CLINICAL COURSE
Haematoxylin-eosin–stained sections demonstrated a moderately dense infiltrate of lymphohistiocytic cells extending from the papillary to the midreticular dermis. Immunocytochemical staining of the lymphocytic infiltrate revealed a predominance of T cells, but some B cells were also identified. Many of the cells stained with the histiocytic markers Mac-387 and CD68. Staining was negative for S100 protein.
On electron microscopy, a population of histiocytes was identified, but no Birbeck granules (specific for Langerhans cells) were present. Dense bodies and comma-shaped bodies were identified in some of the cells.
During 4 years of follow-up, the patient has received no specific treatment and continues to develop occasional new lesions. There has been no clinical indication of disease transformation or development of systemic disease.
DISCUSSION
Generalized eruptive histiocytoma, which is a rare non–Langerhans cell (non-X), nonlipidic, self-healing histiocytosis, was first described by Winkelmann and Muller1 in 1963. It mainly affects adults, with only 10 cases reported . . . [Full Text of this Article]
