This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (1)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Dermatologic Disorders  • Dermatologic Disorders, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Although the syndrome of erythromelalgia has been well documented in recent years, the reason that the extremities suddenly turn hot and red remains elusive. In recent years, some clues have been elucidated, such as increased blood flow, microvascular shunting, increased local metabolism, and small-fiber neuropathy. Although there are anecdotal reports of the occurrence of Raynaud phenomenon in erythromelalgia,^1-5 few studies have systematically described the affected extremities between episodes (most describe the extremities during symptoms). An understanding of the changes between episodes of erythromelalgia may provide further clues to the pathogenesis.

Anecdotally, we noted that many patients complain of discomfort and have cool, discolored extremities between episodes of erythromelalgia, features that are indicative of acrocyanosis or even Raynaud phenomenon (Figure). These findings suggest that the syndrome of erythromelalgia is a vasculopathy not only during episodes of a flare but also between flares: conceptually, an unstable vasculature in the extremities. . . . [Full Text of this Article]

AUTHOR INFORMATION
Mark D. P. Davis, MD; Francesca Wilkins, MD; Thom W. Rooke, MD

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?