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Alitretinoin as a Potential Advance in the Management of Severe Chronic Hand Eczema
John R. Ingram, DM;
Jonathan M. Batchelor, BMBS;
Hywel C. Williams, PhD
Arch Dermatol. 2009;145(3):314-315.
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Commentary on: Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial
Ruzicka T, Lynde CW, Jemec GB, et al
Br J Dermatol. 2008;158(4):808-817
Question: Is oral alitretinoin, at a dose of 10 or 30 mg once daily, an effective and safe treatment for severe chronic hand eczema (CHE) refractory to topical corticosteroids?
Design: Randomized controlled trial.
Setting: Multicenter trial performed in 111 dermatology outpatient clinics in Europe and Canada.
Patients: A total of 1032 patients with severe chronic hand eczema of at least 6 months' duration and refractory to standard therapy were randomized; 759 completed the trial period. Study groups had similar baseline characteristics.
Interventions: Participants were randomized in a 1:2:2 ratio to . . . [Full Text of this Article] Comment
AUTHOR INFORMATION
Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff (Dr Ingram); Department of Dermatology, Addenbrooke's Hospital, Cambridge, England (Dr Batchelor); and Centre of Evidence-Based Dermatology, University of Nottingham, King's Meadow Campus, Nottingham (Dr Williams), England
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